Liver stiffness, hepatorenal index, and microRNA-130b as predictors for chronic kidney disease in patients with non-alcoholic fatty liver disease

Abstract Background and aim Currently, nonalcoholic liver disease (NAFLD) is the most predominant chronic disorder. NAFLD has been linked to hepatic extrahepatic morbidities. We aimed investigate role of acoustic radiation force impulse (ARFI), hepatorenal index (HRI), serum microRNA-130b as non-invasive predictors for kidney (CKD) in patients. Material methods In a case–control design, we included 40 patients (20 with CKD 20 without CKD) healthy controls. After clinical evaluation, laboratory assessments including test profile, renal function test, quantification were done. Liver steatosis stiffness evaluated using HRI ARFI. Results ARFI readings significantly higher among compared other groups ( P < 0.001). The median values 32.1, 27.01, 25.36 copies/µl CKD, controls, respectively, significant differences between 0.05). positively correlated At cutoff value > 28.13 copies/µl, could differentiate “NAFLD CKD” sensitivity specificity 75% 70%, respectively AUC = 71.9%, 0.018). Conclusions Serum microRNA-130b, HRI, are valuable noninvasive markers assessment NAFLD. MicroRNA-130b suggested sensitive biomarker prediction good specificity.